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Muscle Building - Creatine

Everything You Wanted to Know About Creatine but were Afraid to Ask

Creatine Insulin Dilema (by Alfredo Franco-Obregón, PhD):
Creatine is, by no means, new to this world. Creatine is, and always has been, a natural constituent of skeletal muscle. Humankind simply needed to be made aware of its existence. Amazingly, creatine was first identified nearly two centuries ago! In the early 1800s, the French scientist and philosopher, Michel-Eugène Chevreul, isolated a novel agent from skeletal muscle that he later named creatine for kreas, the Greek word for flesh (1). A few years later (1847), a German scientist named Justus von Liebig observed that maintaining foxes in captivity decreased their muscular creatine content (2). Postulating that physical activity increases creatine uptake by skeletal muscle, Liebig advanced the hypothesis that muscles utilize certain nitrogen containing molecules for energy. These nitrogenous molecules, otherwise known as amino acids, include creatine. Intriguingly, as an extension of his findings, Liebig later lent his name to a commercial extract of meat, which he asserted would help the body perform extra "work". In fact, "Liebig's Fleisch Extrakt" could quite reasonably be considered the original creatine supplement (complete with marketing plan). Near the turn of the last century the first studies examining the effects of creatine feeding were conducted where it was noticed that not all the creatine fed to animals could be recovered in the urine. Soon afterwards, Otto Folin and W. Dennis (1912-1914) of Harvard University (Boston) unequivocally corroborated by that the body’s musculature retains the greater part of any ingested creatine. More »

Do Creatine and Alcohol Mix? (by Alfredo Franco-Obregón, PhD):
Although no published studies have specifically examined the effects of alcohol on the effectiveness of creatine, alcohol does have known effects on muscle metabolism and survival. These indirect consequences of alcohol consumption might, in turn, influence how well one responds to creatine supplementation. However, in order to get the full gist of the arguments I will make, a little background is necessary. More »

Creatine: Not just a sports nutrition supplement (by Will Brink):
Readers of the March 2003 issue of Life Extension magazine should recall the long list of potential medical, performance and anti-aging effects of creatine. The article outlined the substantial body of research that found creatine may help with diseases effecting the neuro muscular system, such as muscular dystrophy and may have therapeutic applications in aging populations, wasting syndromes, muscle atrophy, fatigue, myopathies, Parkinson's disease, Huntington's disease and other mitochondrial cytopathies. Several studies have shown it may reduce cholesterol by up to 15% and has been used to correct certain inborn errors of metabolism, such as people born without the enzyme(s) responsible for making creatine. More »